HIV-1 Reverse Transcriptase-Inhibitory Compound in Salvia officinalis.
نویسندگان
چکیده
منابع مشابه
Conformational changes in HIV-1 reverse transcriptase induced by nonnucleoside reverse transcriptase inhibitor binding.
Nonnucleoside reverse transcriptase inhibitors (NNRTI) are a group of small hydrophobic compounds with diverse structures that specifically inhibit HIV-1 reverse transcriptase (RT). NNRTIs interact with HIV-1 RT by binding to a single site on the p66 subunit of the p66/p51 heterodimeric enzyme, termed the NNRTI-binding pocket (NNRTI-BP). This binding interaction results in both short-range and ...
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HIV-1 reverse transcriptase (RT) plays a central role in HIV infection. Current United States Federal Drug Administration (USFDA)-approved antiretroviral therapies can include one of five approved non-nucleoside RT inhibitors (NNRTIs), which are potent inhibitors of RT activity. Despite their crucial clinical role in treating and preventing HIV-1 infection, their mechanism of action remains elu...
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Background HIV-1 reverse transcriptase (HIV-1 RT) is an essential enzyme for the replication cycle of HIV. HIV-1 RT inhibitors have been extensively investigated for their antiHIV properties. However, emergence of HIV drug resistance and side effects are the main reasons for failure of anti-HIV therapy. The aim of the present study was to evaluate the HIV reverse transcriptase inhibitory activi...
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Based on an established common pharmacophore of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNTTIs), a series of quinolin-2-one derivatives were synthesized and assayed for their in vitro activities against HIV-1 reverse transcriptase (RT) for the first time. Some of the tested compounds were active against HIV-1 RT. Compounds 4a2 and 4d2 showed inhibitory activities with IC(50) valu...
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BACKGROUND Acquired immunodeficiency syndrome (AIDS), which is caused by the human immunodeficiency virus (HIV), is an immunosuppressive disease that results in life-threatening opportunistic infections. The general problems in current therapy include the constant emergence of drug-resistant HIV strains, adverse side effects and the unavailability of treatments in developing countries. Natural ...
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ژورنال
عنوان ژورنال: Food Science and Technology Research
سال: 2000
ISSN: 1344-6606,1881-3984
DOI: 10.3136/fstr.6.216